The Definitive Guide to pharmaceutical purified water system qualification
Except systems are particularly suitable for this, temperatures hotter than eighty˚C can effect the longevity of system elements (e.g. gaskets and diaphragms). A temperature of 80˚C is well warm sufficient to kill one of the most warmth resistant biofilm organisms that may colonize a water system (D value of about 5 milliseconds).Microbial Contam